Table 4.

Hazard ratios for death from any cause as function of serum cholesterol in cohort that received diets for one year or more (n=2355)*

	Intervention	Control	Both groups
All participants
No in group	1179	1176	2355
HR (95% CI), P value:
Crude†	1.45 (1.27 to 1.66), <0.001	1.44 (1.17 to 1.76), <0.001	1.39 (1.23 to 1.58), <0.001
Adjusted‡	1.22 (1.04 to 1.44), 0.016	1.28 (1.09 to 1.51), 0.003	1.22 (1.14 to 1.32), <0.001
Sensitivity§	1.20 (1.03 to 1.41), 0.023	1.32 (1.11 to 1.57), 0.002	1.24 (1.15 to 1.33), <0.001
Participants aged <65
No in group	886	874	1760
HR (95% CI), P value:
Crude†	1.02 (0.60 to 1.73), 0.936	1.17 (0.82 to 1.69), 0.389	1.07 (0.93 to 1.23), 0.368
Adjusted‡	0.92 (0.61 to 1.37), 0.680	1.12 (0.79 to 1.57), 0.525	1.01 (0.88 to 1.16), 0.924
Sensitivity§	0.94 (0.58 to 1.53), 0.816	1.16 (0.79 to 1.70), 0.448	1.02 (0.91 to 1.16), 0.703
Participants aged ≥65
No in group	293	302	595
HR (95% CI), P value:
Crude†	1.55 (1.39 to 1.71), <0.001	1.53 (1.24 to 1.88), <0.001	1.50 (1.31 to 1.71), <0.001
Adjusted‡	1.42 (1.22 to 1.67), <0.001	1.39 (1.10 to 1.76), 0.006	1.35 (1.18 to 1.54), <0.001
Sensitivity§	1.36 (1.17 to 1.58), <0.001	1.43 (1.14 to 1.78), 0.002	1.35 (1.19 to 1.53), <0.001

*Cox regressions for death as function of time varying serum cholesterol concentration. All estimates represent hazard ratio for a serum cholesterol decrease of 30 mg/dL (0.78 mmol/L). All models account for clustering within hospital.

†Model adjusted for baseline serum cholesterol concentration.

‡Adjusted for baseline serum cholesterol concentration, age, BMI, sex, adherence to diet, and systolic blood pressure (SBP).

§Further adjusted for time varying percentage change from baseline for BMI and SBP.