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. 2016 Apr 19;11(4):e0153316. doi: 10.1371/journal.pone.0153316

Fig 2. SNPs associated with seropositivity in RA.

Fig 2

Redundancy discrimination analysis plot showing that IRF5, CD28 and CTLA4 are associated with seropositivity in RA patients. RF+–rheumatoid factor positive RA patients; RF-–rheumatoid factor negative RA patients; ACPA+–anti-citrullinated peptides antibodies positive RA patients; ACPA-–anti-citrullinated peptides antibodies negative RA patients; SE (0,1,2)—number of shared epitope coding alleles in HLA-DRB1 gene (✧); IRF5 (CC, CT, TT)—genotypes in IRF5 gene (C risk allele) (▷); CD28 (CC, CT, TT)–genotypes in CD28 gene (C risk allele) (◁); CTLA4 (AG, GG, AA)–genotypes in CTLA4 gene (G risk allele) (◊). Diagram reading clue: Symbols are genetic factors. Large bold symbols represent genotypes significantly influencing the presence of RF and ACPA. Small empty symbols represent other genotypes of selected genes. Direction of arrow indicates which serologic status is associated with the genetic parameters and the length of the arrow indicates the magnitude of the association.