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. 2016 Apr 19;11(4):e0153316. doi: 10.1371/journal.pone.0153316

Fig 3. Factors associated with clinical severity in RA.

Fig 3

Redundancy analysis plot showing that risk alleles in AFF3 gene, together with ACPA positivity are associated with higher clinical severity of RA. ACPA—anti-citrullinated peptides antibodies (□); AFF3 (TT, AT, AA)–genotypes in AFF3 gene (T risk allele) (▽). Diagram reading clue: Symbols are genetic and serologic factors. Large bold symbols represent genotypes and antibody presence significantly influencing the clinical parameters of disease severity (DAS28, CRP, ESR, TJC, SJC, HAQ-DI). Small empty symbols represent other factors and genotypes of selected genes. Direction of arrow indicates which of the clinical factors are associated with the genetic and serologic parameters and the length of the arrow indicates the magnitude of the association.