Table 2. Allelic frequencies of all studied genes and their association with RA.
| SNPa | Allele | Allele frequency (%) | Association with RA (χ2c) | ||||
|---|---|---|---|---|---|---|---|
| Gene | IDb | Major | Minor | RA | C | p value | ORd (95% CIe) |
| HLA-DRB1 | - | - | - | - | - | <0.0001 | 2.54 (2.1–3.08) |
| PTPN22 | rs2476601 | C | T | 14.6 | 10.8 | 0.003 | 1.43 (1.13–1.80) |
| STAT4 | rs7574865 | G | T | 26.8 | 22.0 | 0.004 | 1.30 (1.09–1.56) |
| CTLA4 | rs3087243 | A | G | 38.3 | 40.5 | 0.253 | 1.10 (0.93–1.30) |
| TRAF1/C5 | rs3761847 | A | G | 41.4 | 43.4 | 0.308 | 0.92 (0.79–1.08) |
| TNFAIP3 | rs5029937 | C | T | 2.2 | 2.5 | 0.599 | 0.87 (0.52–1.47) |
| AFF3 | rs11676922 | A | T | 46.9 | 47.2 | 0.889 | 0.99 (0.84–1.16) |
| IRF5 | rs10488631 | T | C | 15.4 | 11.6 | 0.004 | 1.41 (1.12–1.78) |
| PADI4 | rs2240340 | C | T | 45.9 | 38.9 | 0.001 | 1.32 (1.13–1.55) |
| CD28 | rs1980422 | T | C | 27.2 | 25.6 | 0.382 | 1.08 (0.90–1.30) |
| CSK | rs34933034 | G | A | 17.8 | 19.3 | 0.377 | 0.91 (0.74–1.12) |
| FCGR3A | rs396991 | A | C | 38.1 | 37.2 | 0.637 | 1.04 (0.88–1.23) |
aSNP, single nucleotide polymorphism.
bID, identification number.
cχ2, Chi-square test.
dOR, Odds ratio.
e95% CI, 95% confidence interval.