Figure 2.

Preexposure prophylaxis (PrEP) does not affect the maturation of T cells. Frequencies of CD4⁺ and CD8⁺ T cells were calculated as fractions of CD3⁺ lymphocytes. CD45RA and CCR7 were used to distinguish naive (CD45RA⁺CCR7⁺), central memory (T_CM; CD45RA⁻CCR7⁺), effector memory (T_EM; CD45RA⁻CCR7⁻) and terminally differentiated effector memory (for CD8⁺ T cells only, T_EMRA; CD45RA⁺CCR7⁻). A, B, Frequency and distribution in the maturation subsets are shown for CD4⁺ (A) and CD8⁺ (B) T cells. C, Frequency of regulatory T cells (Tregs; CD127^loCD25⁺FoxP3⁺) was calculated as a percentage of either CD4⁺ or CD3⁺ T cells, and expression of activation markers was calculated as the percentage of the total Treg population.