Table 2.
Response Rates for CD8+ and CD4+ T Cells and NK Cells
| Cell Type and Stimulus | Markers | No. (%) Responding |
OR (95% CI) | P Value | |||
|---|---|---|---|---|---|---|---|
| PrEP Group | No. | Placebo Group | No. | ||||
| CD8+ T cells | |||||||
| Any | |||||||
| IFN-γ and CD107a | 23 (20.0) | 115 | 20 (17.4) | 115 | 1.2 (.6–2.5) | .53 | |
| IFN-γ and TNF-α | 58 (50.4) | 115 | 59 (51.3) | 115 | 0.9 (.6–1.5) | .73 | |
| Gag | |||||||
| IFN-γ and CD107a | 16 (14.0) | 114 | 15 (13.0) | 115 | 1.1 (.5–2.3) | .83 | |
| IFN-γ and TNF-α | 50 (43.9) | 114 | 50 (43.5) | 115 | 1.0 (.6–1.7) | .95 | |
| Env | |||||||
| IFN-γ and CD107a | 16 (14.8) | 108 | 15 (13.5) | 111 | 1.1 (.5–2.4) | .78 | |
| IFN-γ and TNF-α | 47 (43.5) | 108 | 51 (45.9) | 111 | 0.9 (.5–1.5) | .72 | |
| Tat | |||||||
| IFN-γ and CD107a | 13 (14.1) | 92 | 7 (7.7) | 91 | 2.0 (.7–5.2) | .16 | |
| IFN-γ and TNF-α | 30 (32.6) | 92 | 35 (38.5) | 91 | 0.8 (.4–1.4) | .41 | |
| CD4+ T cells | |||||||
| Any | |||||||
| IFN-γ and TNF-α | 10 (8.7) | 115 | 11 (9.6) | 115 | 0.8 (.3–2.1) | .62 | |
| Gag | |||||||
| IFN-γ and TNF-α | 8 (7.0) | 114 | 8 (7.0) | 115 | 1.0 (.4–2.8) | .99 | |
| Env | |||||||
| IFN-γ and TNF-α | 4 (3.7) | 108 | 7 (6.3) | 111 | 0.6 (.2–2.0) | .37 | |
| Tat | |||||||
| IFN-γ and TNF-α | 2 (2.2) | 91 | 5 (5.5) | 91 | 0.4 (.1–2.0) | .24 | |
| NK cells | |||||||
| Any | |||||||
| IFN-γ and CD107a | 18 (15.8) | 114 | 11 (9.6) | 116 | 1.2 (.5–2.7) | .66 | |
| Gag | |||||||
| IFN-γ and CD107a | 10 (8.8) | 113 | 9 (7.9) | 116 | 1.1 (.4–2.9) | .80 | |
| Env | |||||||
| IFN-γ and CD107a | 15 (14.0) | 107 | 10 (9.2) | 111 | 1.6 (.7–3.8) | .26 | |
| Tat | |||||||
| IFN-γ and CD107a | 4 (4.3) | 92 | 7 (7.9) | 92 | 0.5 (.2–1.9) | .32 | |
Abbreviations: CI, confidence interval; IFN, interferon; NK, natural killer; OR, odds ratio; PrEP, preexposure prophylaxis; TNF, tumor necrosis factor.