Table 2. Adjusted linear regression analyses with change in augmentation index (ΔAIx), pulse wave velocity (ΔaPWV), systolic (∆sBP) and diastolic (∆dBP) blood pressure as dependent variables.
| ∆AIx (%) | ∆aPWV (m/s2) | ∆sBP (mmHg) | ∆dBP (mmHg) | |
|---|---|---|---|---|
| β (95% CI)*p-value | β (95% CI)* p-value | β (95% CI)† p-value | β (95% CI)†p-value | |
| Baseline Aix (%) | -0.53 (-0.74, -0.32) p<0.001 | -0.34 (-1.47, 0.79) p = 0.55 | -0.02 (-0.58, 0.54) p = 0.95 | 0.08 (-0.24, 0.39) p = 0.63 |
| Baseline aPWV (m/s2) | -0.01 (-0.06, 0.04) p = 0.67 | -0.44 (-0.66, -0.22) p<0.001 | -5.22 (-8.04,-2.40) p<0.001 | -2.73 (-4.32, 1.14) p = 0.001 |
| Baseline sBP (mmHg) | -0.02 (-0.11, 0.07) p = 0.73 | -0.01 (-0.03, 0.01) p = 0.25 | -0.55 (-0.72, -0.39) p<0.001 | -0.24 (-0.34, -0.14) p<0.001 |
| Baseline dBP (mmHg) | -0.13 (-0.31, 0.04)p = 0.14 | 0.001 (-0.03, 0.04)p = 0.95 | -0.71 (-1.09, -0.32) p<0.001 | -0.56 (-0.75, -0.36) p<0.001 |
| ∆AIx(%) | 0.01 (-0.50, 0.53) p = 0.96 | -0.02 (-0.31, 0.27)p = 0.90 | ||
| ∆aPWV(m/s2) | 8.41 (5.88, 10.94)p<0.001 | 4.04 (2.51, 5.58)p<0.001 | ||
| ∆sBP(mmHg) | 0.004 (-0.09, 0.10) p = 0.93 | 0.04 (0.02, 0.06) p<0.001 | ||
| ∆dBP(mmHg) | -0.02 (-0.19, 0.15) p = 0.84 | 0.05 (0.02, 0.08) p = 0.002 |
* Adjusted for age, sex and change of/initiation of antihypertensive therapy during the study period.
† Adjusted for age and gender. Excluding patients for whom antihypertensive therapy was changed/initated.
Δ: change during study period, CI: confidence interval, aPWV: aortic pulse wave velocity, AIx: Augmentation index, sBP: systolic blood pressure, dBP: diastolic blood pressure.