Skip to main content
. 2016 Apr 19;11(4):e0153932. doi: 10.1371/journal.pone.0153932

Table 3. Regulation of DE genes involved in relevant pathways between clinical and uninfected control animals.

Gene ID Description Log2 Fold Change P-value FDR
T-Cell Receptor Pathway
ENSBTAG00000004322 FBJ murine osteosarcoma viral oncogene homolog (FOS) 2.42 1.78E-11 1.55E-08
ENSBTAG00000010007 mitogen-activated protein kinase 13 (MAPK13/p38δ) 0.99 3.73E-04 1.08E-02
ENSBTAG00000004037 jun proto-oncogene (JUN) 0.85 1.52E-03 2.90E-02
ENSBTAG00000009494 Cas-Br-M (murine) ecotropic retroviral transforming sequence c (CBLC) 0.73 1.41E-03 2.77E-02
ENSBTAG00000013851 B-cell CLL/lymphoma 10 (BCL10) 0.69 1.76E-03 3.18E-02
ENSBTAG00000007084 mitogen-activated protein kinase kinase kinase 14 (MAP3K14) (NIK) -0.69 5.15E-04 1.38E-02
ENSBTAG00000006909 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.79 2.29E-03 3.86E-02
ENSBTAG00000018984 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -0.97 1.00E-03 2.18E-02
ENSBTAG00000023144 protein tyrosine phosphatase, receptor type, C -0.97 3.08E-04 9.56E-03
ENSBTAG00000006452 CD3d molecule, delta (CD3-TCR complex) (CD3D) -1.00 3.07E-03 4.72E-02
ENSBTAG00000012695 lymphocyte-specific protein tyrosine kinase (LCK) -1.05 1.64E-03 3.05E-02
ENSBTAG00000014698 caspase recruitment domain family, member 11 (CARD11) -1.10 1.57E-04 6.13E-03
ENSBTAG00000021872 RAS guanyl releasing protein 1 (calcium and DAG-regulated) (RASGRP1) -1.11 7.24E-04 1.74E-02
ENSBTAG00000018270 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (NFAT) -1.19 6.33E-04 1.57E-02
ENSBTAG00000017843 CD40 ligand (CD40LG) -1.45 2.05E-03 3.57E-02
ENSBTAG00000011543 programmed cell death 1 (PDCD1) -1.63 2.82E-03 4.45E-02
B-Cell Receptor Pathway
ENSBTAG00000004322 FBJ murine osteosarcoma viral oncogene homolog (FOS) 2.42 1.78E-11 1.55E-08
ENSBTAG00000004037 jun proto-oncogene (JUN) 0.85 1.52E-03 2.90E-02
ENSBTAG00000013851 B-cell CLL/lymphoma 10 (BCL10) 0.69 1.76E-03 3.18E-02
ENSBTAG00000006909 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.79 2.29E-03 3.86E-02
ENSBTAG00000018984 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -0.97 1.00E-03 2.18E-02
ENSBTAG00000014698 caspase recruitment domain family, member 11 (CARD11) -1.10 1.57E-04 6.13E-03
ENSBTAG00000020173 inositol polyphosphate-5-phosphatase, 145kDa (INPP5D) -1.18 1.63E-04 6.30E-03
ENSBTAG00000018270 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -1.19 6.33E-04 1.57E-02
ENSBTAG00000008006 RAS guanyl releasing protein 3 (calcium and DAG-regulated) (RASGRP3) -1.56 9.89E-04 2.17E-02
ENSBTAG00000001882 CD79a molecule, immunoglobulin-associated alpha (CD79A) -2.35 3.84E-05 2.36E-03
ENSBTAG00000044204 CD79b molecule, immunoglobulin-associated beta -2.97 9.65E-05 4.39E-03
Lysosomal Pathway
ENSBTAG00000021035 cathepsin K (CTSK) 4.01 4.62E-13 6.23E-10
ENSBTAG00000000133 CD68 molecule (CD68) 2.40 3.26E-07 6.55E-05
ENSBTAG00000010992 cathepsin H (CTSH) 1.63 3.81E-05 2.36E-03
ENSBTAG00000003636 lipase A, lysosomal acid, cholesterol esterase 1.54 9.10E-05 4.27E-03
ENSBTAG00000017465 glucosamine (N-acetyl)-6-sulfatase (GNS) 1.50 1.96E-06 2.67E-04
ENSBTAG00000012442 cathepsin B (CTSB) 1.49 8.69E-05 4.17E-03
ENSBTAG00000018784 cathepsin Z (CTSZ) 1.13 1.65E-04 6.33E-03
ENSBTAG00000011100 cathepsin C (CTSC) 1.04 1.33E-03 2.66E-02
ENSBTAG00000017077 cathepsin L2 (CTSL2) 0.94 2.48E-03 4.05E-02
ENSBTAG00000017135 cathepsin S (CTSS) 0.94 9.33E-04 2.09E-02
ENSBTAG00000015512 hexosaminidase B (beta polypeptide) (HEXB) 0.92 1.18E-04 5.02E-03
ENSBTAG00000008341 arylsulfatase B (ARSB) -1.18 1.47E-04 5.87E-03
ENSBTAG00000006552 lysosomal-associated membrane protein 3 (LAMP3) -1.22 9.80E-05 4.42E-03
ENSBTAG00000006780 napsin A aspartic peptidase -2.10 2.32E-03 3.90E-02