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. 2016 Apr 19;11(4):e0153932. doi: 10.1371/journal.pone.0153932

Table 6. Regulation of DE genes involved in relevant pathways between clinical and subclinical animals.

Gene ID Description Log2 Fold Change P-value FDR
Lysosomal pathway
ENSBTAG00000021035 cathepsin K (CTSK) 3.92 5.46E-15 1.66E-11
ENSBTAG00000000133 CD68 molecule (CD68) 2.98 1.77E-11 1.95E-08
ENSBTAG00000007622 cathepsin D (CTSD) 1.97 8.05E-06 1.28E-03
ENSBTAG00000017465 glucosamine (N-acetyl)-6-sulfatase (GNS) 1.63 2.40E-08 1.42E-05
ENSBTAG00000011100 cathepsin C (CTSC) 1.53 4.58E-07 1.63E-04
ENSBTAG00000018784 cathepsin Z (CTSZ) 1.52 7.22E-08 3.24E-05
ENSBTAG00000012442 cathepsin B (CTSB) 1.46 3.33E-05 4.09E-03
ENSBTAG00000010992 cathepsin H (CTSH) 1.46 6.36E-05 6.07E-03
ENSBTAG00000003636 lipase A, lysosomal acid, cholesterol esterase 1.35 1.96E-04 1.49E-02
ENSBTAG00000011257 N-acylsphingosine amidohydrolase (acid ceramidase) 1 (ASAH1) 0.96 7.08E-05 6.50E-03
ENSBTAG00000027337 cathepsin A (CTSA) 0.94 2.10E-04 1.56E-02
ENSBTAG00000015512 hexosaminidase B (beta polypeptide) (HEXB) 0.92 3.17E-05 3.96E-03
ENSBTAG00000019256 galactosidase, alpha 0.85 6.17E-04 3.65E-02
ENSBTAG00000008341 arylsulfatase B (ARSB) -0.99 8.22E-04 4.41E-02
Complement and Coagulation Pathway
ENSBTAG00000020872 complement component 5a receptor 1 (C5AR1) 2.30 2.17E-06 5.48E-04
ENSBTAG00000007101 coagulation factor III (F3) 2.22 1.05E-15 4.25E-12
ENSBTAG00000013125 plasminogen activator, urokinase receptor (PLAUR) 2.13 1.57E-05 2.14E-03
ENSBTAG00000006984 CD55 molecule, decay accelerating factor for complement (CD55) 1.97 2.77E-05 3.65E-03
ENSBTAG00000005947 plasminogen activator, urokinase (PLAU) 1.52 1.86E-06 4.89E-04
ENSBTAG00000007411 coagulation factor VII (serum prothrombin conversion accelerator) (F7) -1.42 2.24E-04 1.65E-02
ENSBTAG00000017714 complement component 4 binding protein, beta -2.24 4.42E-04 2.86E-02
NOD-like Receptor Signaling Pathway
ENSBTAG00000038235 nucleotide-binding oligomerization domain containing 1 (NOD1) 2.05 5.44E-08 2.64E-05
ENSBTAG00000019716 interleukin 8 (IL8) 1.77 4.59E-05 4.97E-03
ENSBTAG00000003326 NLR family, apoptosis inhibitory protein 1.74 2.99E-06 6.49E-04
ENSBTAG00000037811 chemokine (C-C motif) ligand 2 (CCL2) 1.61 8.25E-04 4.41E-02
ENSBTAG00000020936 nucleotide-binding oligomerization domain containing 2 (NOD2) 0.94 4.42E-04 2.86E-02
ENSBTAG00000010007 mitogen-activated protein kinase 13 (MAPK13) 0.87 8.50E-04 4.52E-02
Leukocyte Transendothelial Migration
ENSBTAG00000020676 matrix metallopeptidase 9 (MMP9) 2.24 5.69E-05 5.57E-03
ENSBTAG00000019953 cytochrome b-245, beta polypeptide (CYBB) 2.20 2.79E-06 6.15E-04
ENSBTAG00000026278 claudin 4 (CLDN4) 1.97 2.01E-10 2.03E-07
ENSBTAG00000008004 neutrophil cytosolic factor 2 1.70 5.30E-04 3.22E-02
ENSBTAG00000010303 intercellular adhesion molecule 1 (ICAM1) 1.58 8.20E-06 1.29E-03
ENSBTAG00000017060 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2) 1.22 3.73E-05 4.43E-03
ENSBTAG00000010007 mitogen-activated protein kinase 13 (MAPK13) 0.87 8.50E-04 4.52E-02