Figure 1.

Cumulative breast cancer risk curves for BRCA1/2 mutation carriers (≥40 years) selected from the Hereditary Breast and Ovarian Cancer Research Group Netherlands cohort opting for risk-reducing salpingo-oophorectomy (RRSO) vs not opting for risk-reducing salpingo-oophorectomy (non-RRSO). *per 1000 person-years of observation. †Univariate analysis. The observation period started at the age of DNA result or the age of 40 years, whichever came first. A robust variance-covariance estimation method was used to correct for nonindependence of observations in women from the same family. BC = breast cancer; CI = confidence interval; HR = hazard ratio; PYO = person-years of observation; RRSO = risk-reducing salpingo-oophorectomy.