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. Author manuscript; available in PMC: 2017 Feb 12.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Jan 12;55(7):2526–2530. doi: 10.1002/anie.201509917

Scheme 4.

Scheme 4

Palladium/(R)-CTH-JAFAPHOS catalyzed AAA with acyclic electrophiles.a

[a] Isolated yields with ee’s determined by chiral HPLC or SFC. [b] 10 mol% catalysis was used. [c] Reaction time was 4h.