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. Author manuscript; available in PMC: 2016 Jun 16.
Published in final edited form as: Nature. 2015 Dec 16;529(7584):43–47. doi: 10.1038/nature16166

Figure 1. A schematic view of how intrinsic processes and extrinsic factors are related to cancer risks through stem-cell division.

Figure 1

This hypothesis maintains the strong role of stem-cell division in imparting cancer risk, but it also illustrates the potential contributions of both intrinsic and extrinsic factors, both operating through stem-cell division. Other effects, e.g. through division of non-stem cells, are not considered here.