Extended Data Figure 5.

Intrinsic cancer risk modeling, Part 2/2: Schema of stem-cell divisions and driver gene mutations based on which the theoretical lifetime intrinsic risks (tLIR) for cancer due to k driver gene mutations are computed.

Here every colored circle represents the mutation of a new driver gene in the given stem cell (yellow: first mutation; green: second mutation; red: third mutation). If the mutation of 3 designated driver genes would induce a cancerous stem cell (k = 3), then this diagram shows a cancer occurrence as the second stem cell in the last generation (generation n) has accumulated all 3 driver gene mutations.