Table 1.
Expert consensus clinical classifications, clinical data, imaging classifications, and neuropathologic diagnoses.
| Clinical Consensus Classification | Age at Initial Evaluation | Age at Imaging Classification | Age at Death | Disease Duration | PiB-DTBZ Imaging Classification | Pathologic Diagnosis | Comment |
|---|---|---|---|---|---|---|---|
| LBD | 75 | 76 | 80 | 5 | LBD | AD | Midbrain Lewy Bodies |
| AD | 59 | 60 | 66 | 7 | AD | AD | |
| AD | 66 | 67 | 70 | 4 | AD | AD | |
| LBD | 68 | 70 | 71 | 3 | LBD | LBD | |
| LBD | 74 | 74 | 78 | 4 | LBD | LBD | Subacute Right Basal Ganglia Infarct |
| AD | 76 | 78 | 80 | 4 | AD | AD | Subacute Left Parahippocampal Infarct |
| mdMCI | 78 | 78 | 83 | 5 | AD | AD | |
| FTD | 71 | 72 | 75 | 4 | FTD | Multiple Infarcts | Frontal and Temporal Atrophy, Multiple Small Infarctions, Mild Loss of Nigral Neurons |
| AD | 64 | 65 | 67 | 3 | AD | AD | |
| AD | 69 | 71 | 73 | 4 | AD | AD | |
| naMCI | 66 | 67 | 71 | 5 | FTD | FTD | C9ORF73 Mutation |
| LBD | 65 | 65 | 67 | 2 | LBD | LBD + AD | |
| LBD | 75 | 79 | 86 | 11 | LBD | LBD | |
| FTD | 71 | 72 | 76 | 5 | AD | AD | |
| LBD | 74 | 74 | 79 | 5 | LBD | LBD | |
| LBD | 65 | 66 | 73 | 8 | LBD | LBD | |
| mdMCI | 65 | 65 | 66 | 1 | AD | AD | |
| FTD | 78 | 80 | 82 | 4 | LBD | TDP-43+ | TDP-43 Immunoreactive Neurites in Frontal Cortex and Hippocampal Formation |
| aMCI | 77 | 80 | 83 | 5 | AD | AD | |
| FTD | 62 | 62 | 63 | 1 | AD | AD | Sparse TDP-43 Immunoreactive Inclusions in Frontal Cortex and Dentate Gyrus |
| AD | 76 | 76 | 80 | 4 | AD | AD + LBD | |
| AD | 64 | 65 | 69 | 5 | AD | AD | |
| naMCI | 62 | 64 | 67 | 5 | LBD | AD + LBD | |
| FTD | 67 | 67 | 71 | 4 | FTD | PSP | |
| AD | 76 | 81 | 82 | 6 | AD | AD | |
| AD | 79 | 79 | 82 | 3 | AD | AD | |
| AD | 85 | 85 | 89 | 4 | AD | AD | |
| naMCI | 78 | 79 | 82 | 4 | FTD | PSP | Remote Cerebellar Infarct |
| AD | 66 | 67 | 72 | 6 | LBD | LBD | |
| aMCI | 79 | 80 | 84 | 5 | AD | AD | |
| CBS | 62 | 66 | 71 | 9 | AD | AD | |
| AD | 55 | 55 | 59 | 4 | AD | AD | |
| AD | 65 | 68 | 72 | 7 | LBD | LBD + AD | |
| LBD | 76 | 77 | 83 | 7 | AD | AD | |
| AD | 56 | 59 | 63 | 7 | AD | AD | |
| AD | 85 | 88 | 92 | 7 | AD | AD | Remote Midbrain Infarct |
| Mean = 70.3 yrs | Mean = 71.6 yrs | Mean = 75.2 yrs | Mean = 4.9 yrs |
Disease duration = interval from age at initial evaluation to age at death. AD = Alzheimer disease, LBD = Lewy body dementia, FTD = Frontotemporal dementia, MCI = Mild Cognitive Impairment, aMCI = Amnestic MCI, naMCI = Non-Amnestic MCI, mdMCI = Multidomain MCI, CBS = Corticobasal syndrome, PSP = Progressive Supranuclear Palsy, PiB-DTBZ = [11C]Pittsburgh B & [11C]dihydrotetrabenazine Positron Emission Tomography, TDP-43 = Transactive response DNA binding protein 43 kDa.