Table 1.
Demographic, Behavioral, and Clinical Characteristics of Cases with Coronary Stenosis >=50% and Matched Controls
| Cases (N=51) | Controls (N=51) | P-Value | Total (n=102) | |
|---|---|---|---|---|
| Age* (years) | 55 (51-58) | 54 (51-59) | 0.81 | 54 (51-58) |
| Race* | 1.00 | |||
| Caucasian (%) | 66.7 | 66.7 | 66.7 | |
| African-American or other (%) | 33.3 | 33.3 | 33.3 | |
| Cohort enrollment period | 0.23 | |||
| pre-2001 (%) | 52.9 | 64.7 | 58.8 | |
| 2001 and later (%) | 47.1 | 35.3 | 41.2 | |
| TMAO quartile | 0.02 | |||
| Q1 (%) | 21.6 | 29.4 | 25.49 | |
| Q2 (%) | 19.6 | 29.4 | 24.51 | |
| Q3 (%) | 39.2 | 11.8 | 25.49 | |
| Q4 (%) | 19.6 | 29.4 | 24.51 | |
| ACC/AHA CVD Risk Score (%) | 8.2 (4.6-14.1) | 5.7 (4.0-10.2) | 0.04 | 6.9 (4.1-12.1) |
| Systolic Blood Pressure (mmHg) | 128 (116-136) | 123 (114-132) | 0.29 | 126 (116-133) |
| On Hypertensive Medications (%) | 35.3 | 27.5 | 0.39 | 31.4 |
| Fasting Glucose (mg/dL) | 101 (92-109) | 98 (90-108) | 0.17 | 99.5 (91-108) |
| On Diabetes Medications (%) | 17.6 | 7.8 | 0.14 | 12.7 |
| Total Cholesterol (mg/dL) | 190 (166-214) | 186 (162-217) | 0.68 | 189.5 (163-216) |
| HDL Cholesterol (mg/dL) | 43.9 (38.9-57.7) | 52.5 (45.5-62.5) | <0.01 | 50.4 (41.5-59.7) |
| On Lipid Lowering Meds (%) | 54.9 | 33.3 | 0.03 | 44.1 |
| Body Mass Index (kg/m2) | 27.0 (23.5-30.8) | 24.8 (22.1-28.5) | 0.08 | 26.0 (22.9-29.3) |
| Current Smoker (%) | 25.5 | 17.6 | 0.34 | 21.6 |
| Cumulative pack yearsa | 10.2 (3.8-41.8) | 8.0 (0.3-21.0) | 0.12 | 9.0 (1.5-27.0) |
| Aspirin use | 45.0 | 18.0 | <0.01 | 31.7 |
| HIV-specific factors | ||||
| HIV-infected* (no. and %) | 28 (54.9) | 28 (54.9) | 56 (54.9) | |
| Viral Load < 50 copies/mL (%) | 71.4 | 89.3 | 0.09 | 80.4 |
| Viral Load log10 copies/mL** | 1.2 (1.0-1.8) | 1.2 (1.0-1.6) | 0.73 | |
| Time on HAART (years) | 9.6 (7.8-12.9) | 9.6 (7.7-12.9) | 0.43 | 9.0 (7.3-12.7) |
| CD4+ T-cell count (cells/mm3) | 667 (417-744) | 562 (434-829) | 0.93 | 614 (424-789) |
| CD4+ T-cell nadir (cells/mm3) | 229 (109-373) | 281 (216-391) | 0.35 | 275 (171-383) |
| History of AIDS (%) | 10.7 | 10.7 | 1.00 | 10.7 |
| Major Coronary Vessel Disease | -- | |||
| Single (%) | 74.5 | -- | -- | |
| Double (%) | 19.6 | -- | -- | |
| Triple (%) | 5.9 | -- | -- |
*
Matching variable. a) Among current and former smokers.
**
Includes men with undetectable viral loads set at 10 copies/mL. Only 11 men had detectable viral loads (8 cases and 3 controls). For those with detectable viral loads: Cases – 3.4 (2.4-3.6); Controls – 3.5 (2.0-5.0) [p=0.68].