Table 1. Descriptive statistics for sample characteristics and study variables by genotype at baseline.
| Val/Val (n=75) | Val/Met or Met/Met (n=37) | ||||
|---|---|---|---|---|---|
|
| |||||
| Characteristic | M ± SD or N (%) | Range | M ± SD or N (%) | Range | P |
| Age | 51.4 ± 8.9 | 31 - 66 | 51.2 ± 7.0 | 34 - 64 | .93a |
| BMI | 25.1 ± 4.8 | 19 - 41 | 24.8 ± 4.6 | 18 - 41 | .73a |
| Education | .69b | ||||
| < College degree | 13 (17.3) | 8 (21.6) | |||
| College degree | 26 (34.7) | 10 (27.0) | |||
| > College degree | 36 (48.0) | 19 (51.4) | |||
| Caucasian ethnicity | 63 (84.0) | 31 (83.8) | .48c | ||
| Sleep quality (PSQI) | 7.17 ± 3.5 | 0 - 16 | 7.8 ± 3.6 | 1 - 16 | .39a |
| Stage at diagnosis | .20c | ||||
| 0 | 8 (10.7) | 9 (24.3) | |||
| 1 | 38 (50.1) | 13 (35.1) | |||
| 2 | 25 (33.3) | 12 (32.4) | |||
| 3 | 4 (5.3) | 3 (8.1) | |||
| Surgery type | .85b | ||||
| Lumpectomy | 52 (69.3) | 25 (67.6) | |||
| Mastectomy | 23 (30.7) | 12 (32.4) | |||
| Cancer treatment | .18c | ||||
| Neither radiation nor chemo | 8 (10.7) | 9 (24.3) | |||
| Radiation only | 29 (38.7) | 11 (29.7) | |||
| Chemo only | 10 (13.3) | 2 (5.4) | |||
| Chemo & radiation | 29 (37.3) | 15 (40.5) | |||
| Time since treatment (mos.) | 1.03 ± .94 | .03 - 4 | 1.4 ± 1.2 | .07 – 3.9 | .09a |
| BDI-II total | 8.93 ± 7.4 | 0 - 35 | 9.22 ± 7.5 | 0 - 32 | .85a |
| BDI-II cognitive | 1.99 ± 2.8 | 0 - 17 | 2.05 ± 3.7 | 0 - 19 | .92a |
| BDI-II affective | 1.48 ± 1.7 | 0 - 7 | 1.70 ± 1.8 | 0 - 7 | .53a |
| BDI-II somatic | 5.46 ± 3.9 | 0 -15 | 5.46 ± 3.7 | 0 - 12 | .99a |
| Inflammatory markers | |||||
| IL-6 (pg/mL) | 1.62 ± .95 | .47 – 5.6 | 1.57 ± 1.06 | .44 – 6.16 | .80a |
| CRP (mg/L) | 2.36 ± 3.1 | .1 – 16.8 | 1.78 ± 2.1 | .1 – 7.8 | .30a |
| sTNF-RII (pg/mL) | 2305.9 ± 614.6 | 1305.7 - 3858 | 2298.2 ± 680.8 | 1354.3 – 3546 | .95a |
a
P-values for independent group t-tests comparing genotype group on continuous variables.
b
P-values from Chi-squared tests comparing genotype groups on categorical variables.
c
P-values from Fisher's exact tests comparing genotype groups on categorical variables with cell means <5.