Table 1.
Base line assessment
| PPHN | Controls | P value | |
|---|---|---|---|
| Number of hearts (n) | 6 | 5 | |
| Animal weight (kg) | 3.43 (0.6) | 2.89 (0.6) | NS |
| Myocardial volume (ml) | 26.83 (4.5) | 16.91 (2.9) | 0.0007 |
| Hemodynamics | |||
| Systemic MAP (mmHg) | 42.2 (17.5) | 56.3 (17.1) | NS |
| Systemic Oxygenation (mmHg) | 23 (12) | 263 (66) | 0.0003 |
| Pulmonary MAP (mmHg) | 39.6 (8.1) | 35.8 (7.7) | NS |
| Pulmonary Blood Flow (ml/kg/min) | 38 (23) | 110 (55) | 0.008 |
| Left ventricle and septum | |||
| Myocardial volume (ml) | 14.8 (1.1) | 9.8 (1.9) | 0.004 |
| Percent of total myocardial volume (%) | 55 (5) | 58 (4) | NS |
| Ventricular volume (ml) | 2.4 (1.4) | 1.5 (0.6) | NS |
| Mitral area (mm2) | 129.3 (44.7) | 96.3 (19.6) | NS |
| Mitral diameter (cm) | 1.2 (0.3) | 1.1 (0.1) | NS |
| Mitral circumference (cm) | 4.3 (0.7) | 3.7 (0.5) | NS |
| LV wall thickness | 6.1 (1.6) | 5.9 (1.2) | NSR |
| Septum wall thickness | 7.5 (1.8) | 6.3 (1.3) | 0.04R |
| Right ventricle | |||
| Myocardial volume (ml) | 12.1 (2.3) | 7.1 (1.3) | 0.0007 |
| Percent of total myocardial volume (%) | 45 (5) | 42 (4) | NS |
| Ventricular volume (ml) | 3.6 (1.8) | 1.6 (2.0) | NS |
| Tricuspid area (mm2) | 97.3 (18.6) | 70.2 (33.2) | NS |
| Tricuspid diameter (cm) | 1.1 (0.1) | 0.9 (0.2) | 0.05 |
| Tricuspid circumference (cm) | 3.9 (0.4) | 3.1 (0.7) | 0.03 |
| RV wall thickness | 6.3 (1.4) | 5.3 (1.1) | NS |
Data presented as means (SD). Means compared using Student’s t-test and repeated measures ANOVA (R).
LV, left ventricle; NS, statistically nonsignificant; PPHN, persistent pulmonary hypertension of the newborn; RV, right ventricle.