Figure 1. PP2A^flox mice develop multi-organ autoimmunity.

(a, b) The body weight (a, n=17 for PP2A^wt and n=9 for PP2A^flox) and the spleen weight (b, n=5 per group) of 10–14 week-old PP2A^wt and PP2A^flox mice were quantified. (c) H&E staining of the lungs, the skin, the pancreas, the salivary glands and the stomach of PP2A^wt and PP2A^flox mice (scale bar represents 200 μm). Images are from one experiment representative of three independent experiments with similar results (n=3 mice per group per experiment). Mean ± s.e.m. is shown, *P<0.001 (unpaired, two-tailed t-test).