miR-186 expression is decreased during aging in the mouse brain cortex. Mature miR-186 levels were analyzed by qRT-PCR in mouse cortex at different ages (n= 8 for 2 month, 6 for 6 month, 7 for 13 month, 6 for 24 month). Each level was represented as a percentage of 2 month old mice. Values are mean ± SEM (*, p<0.05; **, p<0.01; One-way ANOVA compared to 2 month with post hoc Holm-Sidak’s test).