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. 2016 Apr 20;7:509. doi: 10.3389/fmicb.2016.00509

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Copyright © 2016 Yamaoka, Matsuyama, Fukushi, Matsunaga, Matsushima, Kuroyama, Kimura, Takeda, Chimuro and Ryo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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No evidence of cross-reactivity with mAbs of other human coronaviruses. (A) Multiple sequence alignments of human coronavirus N proteins. Shaded positions represent conserved residues among the sequences. Dashes indicate gaps in the aligned sequences. (B) Specificity of selected mAbs. His-tagged NPs derived from several human coronaviruses were produced in the wheat germ extract system. Reactivity of generated mAbs was validated by immunoblot analysis using either anti-His or the indicated antibodies.