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. 2016 Feb 12;21(3):485–497. doi: 10.1007/s12192-016-0677-5

Table 1.

Structures of cytoprotective benzyl piperazine benzamide compounds (AMC)

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CSM14.1 cells were treated with thapsigargin (15 μM) after pre-incubation with various concentration of AMC-01 or its structural derivative

Cellular levels of ATP were evaluated using triplicate samples. Data were analyzed using a dose–response equation with non-linear regression using GraphPad Prism to calculate the EC50 required to sustain a level of 50 % relative cell survival

A reference dose–response curve for each compound is shown in Fig. 1e. Structures of the AMC compound scaffolds are presented with seven variable positions (R1–R7)