Figure 4.

Graphs showing reduction in CCR6⁺CXCR3^–CCR4⁺CD161⁺ T helper cells in patients with chronic mucocutaneous candidiasis (CMC) compared to healthy controls. (a) Graph showing % of CCR6⁺CXCR3^–CCR4⁺CD161⁺ cells within the CD4⁺ T cell population in healthy controls versus individual patient groups. (b) Graph showing absolute counts (×10⁶/l) of CCR6⁺CXCR3^–CCR4⁺CD161⁺ CD4⁺ T cells in healthy controls versus individual patient groups. HC = healthy controls; STAT1 = CMC due to STAT1 mutation; FHx STAT1 = STAT1 wild‐type individual (III.7) from the kindred CMC due to signal transducer and activator of transcription‐1 (STAT‐1) gain‐of‐function (GOF); STAT3 = hyper‐immunoglobulin (Ig)E syndrome due to STAT‐3 deficiency; IL 12RB1 = IL‐12RB1 deficiency; AIRE = APS1 due to AIRE deficiency; *P < 0·05.