Table 3.
Performance characteristics of ex‐vivo assay for T helper type 17 (Th17) cells based on receiver operating characteristic (ROC) curve analysis for (a) percentage (%) and (b) absolute counts (×106/l) using full or condensed antibody panels.
| (a) | Optimal cut‐off | Sensitivity% | Specificity% | AUC |
|---|---|---|---|---|
| CCR6+CXCR3–CCR4+CD161+ | <1·5 | 100·0 | 100·0 | 1·000 |
| CCR6+CXCR3–CCR4+ | <3·6 | 100·0 | 100·0 | 1·000 |
| **CCR6+CXCR3–** | <5·0 | 100·0 | 100·0 | 1·000 |
| CCR6+ | <15·0 | 83·3 | 100·0 | 0·900 |
| (b) | Optimal cut‐off | Sensitivity% | Specificity% | AUC |
|---|---|---|---|---|
| CCR6+CXCR3–CCR4+CD161+ | <11·3 | 100·0 | 100·0 | 1·000 |
| CCR6+CXCR3–CCR4+ | <28·7 | 100·0 | 100·0 | 1·000 |
| **CCR6+CXCR3–** | <32·9 | 100·0 | 100·0 | 1·000 |
| CCR6+ | <122·0 | 100·0 | 85·0 | 0·970 |
AUC = area under the curve.