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. 2016 Apr 6;2016:2953072. doi: 10.1155/2016/2953072

Figure 4.

Figure 4

The relationship between serum levels of κ/λ hybrid antibody and disease activity in RA. (a) Levels of κ/λ hybrid antibody in the serum of RA patients positively correlated with DAS28 (r = 0.41, p = 0.008). (b) The distribution of κ/λ hybrid antibody in RA patients with different disease activity status; RA disease activity on the basis of DAS28 was defined as follows: remission and low = DAS28 < 3.2 (n = 10), moderate = DAS28 between 3.2 and 5.1 (n = 16), and high = DAS28 > 5.1 (n = 22); the κ/λ hybrid antibody levels were significantly higher in the high and moderate disease activity groups than in the low disease activity and remission groups (p = 0.008 and p = 0.0008, resp.); the differences of κ/λ hybrid antibody levels between groups were assessed using the Mann-Whitney U test, ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001. (c, d) Levels of κ/λ hybrid antibody in the serum of RA patients correlated with ESR (r = 0.52, p < 0.0001) and CRP (r = 0.35, p = 0.008). Concentrations of κ/λ hybrids antibody are presented in arbitrary units (AU/mL). Symbols represent individual subjects. Correlations were determined by Spearman's rank correlation coefficients with 95% confidence interval.