Table 2. Meta-analysis of the association between the MMP-9-1562 C/Tpolymorphism and periodontitis.
| Genetic Model and Subgroup | Subgroups | N | Test of Association | Test of Heterogeneity | P* value | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P value | Model | P value | I2(%) | ||||
| T vs. C | Overall | 9 | 0.58 | 0.37–0.90 | 0.015 | R | <0.001 | 88.2 | 0.039 |
| HWE (yes) | 6 | 0.8 | 0.64–1.00 | 0.052 | F | 0.198 | 31.6 | ||
| AgP | 2 | 0.93 | 0.67–1.29 | 0.656 | F | 0.496 | 0 | ||
| CP | 7 | 0.49 | 0.31–0.77 | 0.002 | R | <0.001 | 85.8 | ||
| Caucasian | 4 | 0.72 | 0.57–0.90 | 0.005 | F | 0.122 | 48.2 | ||
| Asian | 3 | 0.39 | 0.20–0.73 | 0.004 | R | <0.001 | 89.9 | ||
| Mixed | 2 | 0.89 | 0.49–1.59 | 0.684 | F | 0.596 | 0 | ||
| HB | 5 | 0.76 | 0.60–0.97 | 0.027 | F | 0.19 | 34.7 | ||
| PB | 4 | 0.44 | 0.25–0.79 | 0.006 | R | <0.001 | 89.7 | ||
| PCR | 4 | 0.72 | 0.57–0.90 | 0.005 | F | 0.122 | 48.2 | ||
| PCR-RFLP | 5 | 0.52 | 0.29–0.93 | 0.029 | R | <0.001 | 87.8 | ||
| Moderate CP | 2 | 0.65 | 0.40–1.07 | 0.09 | F | 0.358 | 0 | ||
| Sever CP | 2 | 0.98 | 0.64–1.50 | 0.926 | F | 0.343 | 0 | ||
| Non-smokers | 2 | 0.67 | 0.46–1.00 | 0.048 | F | 0.86 | 0 | ||
| TT vs. CC | Overall | 9 | 0.17 | 0.13–0.23 | <0.001 | F | 0.217 | 25.6 | 0.121 |
| HWE (yes) | 6 | 0.4 | 0.18–0.89 | 0.026 | F | 0.405 | 1.7 | ||
| AgP | 2 | 0.74 | 0.05–12.16 | 0.836 | R | 0.082 | 66.8 | ||
| CP | 7 | 0.16 | 0.12–0.22 | <0.001 | F | 0.564 | 0 | ||
| Caucasian | 4 | 0.3 | 0.12–0.76 | 0.011 | F | 0.578 | 0 | ||
| Asian | 3 | 0.18 | 0.09–0.38 | <0.001 | R | 0.043 | 68.1 | ||
| Mixed | 2 | 0.23 | 0.02–2.25 | 0.206 | F | 0.883 | 0 | ||
| HB | 5 | 0.29 | 0.12–0.72 | 0.008 | F | 0.718 | 0 | ||
| PB | 4 | 0.19 | 0.10–0.36 | <0.001 | R | 0.083 | 55 | ||
| PCR | 4 | 0.3 | 0.12–0.76 | 0.011 | F | 0.578 | 0 | ||
| PCR-RFLP | 5 | 0.16 | 0.11–0.22 | <0.001 | F | 0.171 | 37.6 | ||
| Moderate CP | 2 | 0.34 | 0.06–2.08 | 0.245 | F | 0.831 | 0 | ||
| Sever CP | 2 | 0.75 | 0.20–2.81 | 0.667 | F | 0.563 | 0 | ||
| Non-smokers | 2 | 1.38 | 0.38–4.92 | 0.623 | F | 0.579 | 0 | ||
| CT vs. CC | Overall | 9 | 0.61 | 0.41–0.93 | 0.02 | R | <0.001 | 74.8 | 0.322 |
| HWE (yes) | 6 | 0.87 | 0.66–1.14 | 0.293 | F | 0.406 | 1.6 | ||
| AgP | 2 | 0.97 | 0.65–1.46 | 0.896 | F | 0.906 | 0 | ||
| CP | 7 | 0.53 | 0.33–0.85 | 0.008 | R | 0.001 | 73.4 | ||
| Caucasian | 4 | 0.75 | 0.57–0.99 | 0.046 | F | 0.192 | 36.8 | ||
| Asian | 3 | 0.39 | 0.19–0.80 | 0.01 | R | 0.008 | 79.4 | ||
| Mixed | 2 | 1.09 | 0.56–2.11 | 0.808 | F | 0.453 | 0 | ||
| HB | 5 | 0.85 | 0.64–1.14 | 0.286 | F | 0.285 | 20.4 | ||
| PB | 4 | 0.43 | 0.25–0.76 | 0.004 | R | 0.007 | 75.3 | ||
| PCR | 4 | 0.75 | 0.57–0.99 | 0.046 | F | 0.192 | 36.8 | ||
| PCR-RFLP | 5 | 0.56 | 0.29–1.09 | 0.09 | R | 0.001 | 79.2 | ||
| Moderate CP | 2 | 0.7 | 0.39–1.24 | 0.218 | F | 0.319 | 0 | ||
| Sever CP | 2 | 1.06 | 0.64–1.74 | 0.667 | F | 0.414 | 0 | ||
| Non-smokers | 2 | 1 | 0.63–1.57 | 0.988 | F | 0.51 | 0 | ||
| TT + CT vs. CC | Overall | 9 | 0.54 | 0.32–0.93 | 0.025 | R | <0.001 | 86.9 | 0.104 |
| HWE (yes) | 6 | 0.82 | 0.63–1.06 | 0.133 | F | 0.276 | 20.9 | ||
| AgP | 2 | 0.95 | 0.64–1.42 | 0.814 | F | 0.798 | 0 | ||
| CP | 7 | 0.46 | 0.26–0.82 | 0.009 | R | <0.001 | 85.8 | ||
| Caucasian | 4 | 0.71 | 0.54–0.93 | 0.013 | F | 0.134 | 46.2 | ||
| Asian | 3 | 0.32 | 0.13–0.77 | 0.011 | R | <0.001 | 89.9 | ||
| Mixed | 2 | 0.98 | 0.51–1.88 | 0.953 | F | 0.512 | 0 | ||
| HB | 5 | 0.79 | 0.59–1.04 | 0.098 | F | 0.21 | 31.7 | ||
| PB | 4 | 0.37 | 0.17–0.78 | 0.009 | R | <0.001 | 88.8 | ||
| PCR | 4 | 0.71 | 0.54–0.93 | 0.013 | F | 0.134 | 46.2 | ||
| PCR-RFLP | 5 | 0.48 | 0.22–1.07 | 0.072 | R | <0.001 | 88.6 | ||
| Moderate CP | 2 | 0.65 | 0.37–1.14 | 0.132 | F | 0.323 | 0 | ||
| Sever CP | 2 | 1.02 | 0.63–1.66 | 0.939 | F | 0.363 | 0 | ||
| Non-smokers | 2 | 1.02 | 0.66–1.58 | 0.935 | F | 0.439 | 0 | ||
| TT vs. CC + CT | Overall | 9 | 0.28 | 0.21–0.36 | <0.001 | F | 0.601 | 0 | 0.379 |
| HWE (yes) | 6 | 0.41 | 0.18–0.93 | 0.033 | F | 0.437 | 0 | ||
| AgP | 2 | 0.75 | 0.05–12.36 | 0.372 | R | 0.08 | 67.3 | ||
| CP | 7 | 0.27 | 0.20–0.35 | <0.001 | F | 0.897 | 0 | ||
| Caucasian | 4 | 0.33 | 0.13–0.83 | 0.018 | F | 0.624 | 0 | ||
| Asian | 3 | 0.27 | 0.21–0.36 | <0.001 | F | 0.119 | 53 | ||
| Mixed | 2 | 0.23 | 0.02–2.22 | 0.202 | F | 0.915 | 0 | ||
| HB | 5 | 0.3 | 0.12–0.75 | 0.01 | F | 0.753 | 0 | ||
| PB | 4 | 0.28 | 0.21–0.37 | <0.001 | F | 0.224 | 31.3 | ||
| PCR | 4 | 0.33 | 0.13–0.83 | 0.018 | F | 0.624 | 0 | ||
| PCR-RFLP | 5 | 0.27 | 0.21–0.36 | <0.001 | F | 0.368 | 6.7 | ||
| Moderate CP | 2 | 0.37 | 0.06–2.26 | 0.284 | F | 0.891 | 0 | ||
| Sever CP | 2 | 0.73 | 0.20–2.72 | 0.64 | F | 0.618 | 0 | ||
| Non-smokers | 2 | 1.35 | 0.38–4.80 | 0.641 | F | 0.618 | 0 | ||
N = number of studies, OR = odds ratio, CI = confidence interval, F = fixed model, R = random model, CP = chronic periodontitis, AgP = aggressive periodontitis, HWE = Hardy-Weinberg equilibrium, HB = hospital-based, PB = population-based.
P* value for publication bias (Egger’s test).