Table 4. Meta-analysis of the association between the MMP-2-753C/T and MMP-8-799C/T polymorphisms and periodontitis.
| Genetic Model and Subgroup | N | T vs. C | TT vs. CC | CT vs. CC | (CT + TT) vs. CC | TT vs. (CC + CT) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | I2 (%) | OR (95% CI) | I2 (%) | OR (95% CI) | I2 (%) | OR (95% CI) | I2 (%) | OR (95% CI) | I2 (%) | ||
| MMP-2-753 C/T | |||||||||||
| Total | 4 | 1.13 (0.88–1.44) | 0 | 1.25 (0.58–2.73) | 0 | 1.14 (0.85–1.53) | 0 | 1.15 (0.87–1.53) | 0 | 1.18 (0.55–2.56) | 0 |
| CP | 2 | 1.11 (0.79–1.55) | 0 | 1.20 (0.43–3.37) | 0 | 1.12 (0.74–1.68) | 0 | 1.12 (0.76–1.66) | 0 | 1.16 (0.42–3.24) | 0 |
| AgP | 2 | 1.15 (0.81–1.64) | 29.9 | 1.33 (0.41–4.31) | 0 | 1.18 (0.77–1.79) | 32.8 | 1.18 (0.78–1.78) | 39.3 | 1.21 (0.38–3.88) | 0 |
| Caucasian | 3 | 1.19 (0.91–1.55) | 0 | 1.33 (0.58–3.03) | 0 | 1.23 (0.89–1.69) | 0 | 1.23 (0.90–1.69) | 0 | 1.24 (0.55–2.80) | 0 |
| Asian | 1 | 0.84 (0.45–1.58) | NA | 0.78 (0.07–8.76) | NA | 0.83 (0.41–1.68) | NA | 0.83 (0.42–1.64) | NA | 0.81 (0.07–9.06) | NA |
| Non-smokers | 3 | 1.27 (0.92–1.75) | 0 | 1.38 (0.52–3.62) | 0 | 1.35 (0.91–2.00) | 0 | 1.35 (0.92–1.97) | 0 | 1.24 (0.48–3.22) | 0 |
| Smokers | 1 | 0.85 (0.36–1.99) | NA | 1.10 (0.09–13.00) | NA | 0.73 (0.26–2.08) | NA | 0.77 (0.28–2.10) | NA | 1.21 (0.10–14.00) | NA |
| MMP-8-799 C/T | |||||||||||
| Total | 4 | 1.61 (1.11–2.35) | 81.6 | 2.26 (1.03–4.97) | 80.8 | 2.18 (1.19–4.00) | 81.5 | 2.22 (1.21–4.08) | 94.5 | 1.44 (0.90–2.16) | 47.3 |
| CP | 2 | 1.28 (1.07–1.54) | 0 | 1.48 (1.02–2.15) | 0 | 1.52 (0.86–2.69) | 72 | 1.48 (1.13–1.95) | 59.9 | 1.25 (0.90–1.73) | 0 |
| AgP | 2 | 2.01 (0.98–4.11) | 85.3 | 3.60 (0.61–21.33) | 88.4 | 3.34 (1.11–10.04) | 81.7 | 3.45 (0.95–12.55) | 87.9 | 1.73 (0.68–4.42) | 70.2 |
| Caucasian | 2 | 1.84 (0.78–4.32) | 93.8 | 3.44 (0.58–20.47) | 93.2 | 2.55 (0.51–12.76) | 93.6 | 2.82 (0.53–14.96) | 94.5 | 1.79 (0.89–3.61) | 75 |
| Asian | 2 | 1.43 (1.11–1.85) | 0 | 1.54 (0.89–2.67) | 0 | 2.03 (1.40–2.93) | 0 | 1.91 (1.35–2.70) | 0 | 1.07 (0.64–1.79) | 0 |
| Non-smokers | 4 | 1.79 (1.19–2.69) | 79.4 | 2.88 (1.21–6.84) | 78.3 | 2.37 (1.24–4.55) | 77.2 | 2.52 (1.30–4.88) | 80.5 | 1.64 (1.19–2.25) | 38.7 |
| Smokers | 1 | 0.91 (0.58–1.42) | NA | 0.81 (0.33–2.00) | NA | 0.96 (0.46–1.99) | NA | 0.91 (0.46–1.82) | NA | 0.84 (0.39–1.81) | NA |
OR = odds ratio, CI = confidence interval, CP = chronic periodontitis, AgP = aggressive periodontitis, NA = not available.