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. 2016 Apr 18;7:11101. doi: 10.1038/ncomms11101

Figure 4. Inheritance of allele-specific behaviour.

Figure 4

(a) The left panel shows plots for the TF CTCF (top row) and ASE (bottom row) being examined for inheritance in the CEU trio (Father: NA12891, blue; Mother: NA12892, red; Child: NA12878, green). Each point on the plot represents the allelic ratio of a common ASB SNV between the parent (x-axis) and the child (y-axis), by computing the proportion of reads mapping to the reference allele at that SNV. High Pearson's correlations, r, observed in both parent-child comparisons for CTCF (r≥0.78) signify strong heritability in allele-specific behaviour. ASE also shows considerably strong evidence of heritability but has comparatively lower r values. (b) The bar plot at the top right panel presents the r values for ASB in two TFs and ASE in our analyses.