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. Author manuscript; available in PMC: 2016 Apr 20.
Published in final edited form as: Cancer Lett. 2015 Jun 26;366(1):123–132. doi: 10.1016/j.canlet.2015.06.015

Figure 7. Proposed working hypothesis for the regulation of LIN28B in neuroblastoma.

Figure 7

(a) MYCN enhances the expression of LIN28B via direct binding at the LIN28B promoter region. In turn, LIN28B inhibits the processing of the let-7 miRNAs, which results in loss of MYCN repression [3]. (b) MYCN indirectly represses the expression of miR-26a-5p via an unknown factor, indicated as “?”. Reduced miR-26a-5p expression levels results in increased LIN28B expression, which again, in turn, inhibits the processing of the let-7 miRNAs, resulting in loss of MYCN repression [3].