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. 2016 Apr 18;7:11344. doi: 10.1038/ncomms11344

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(a) Cartoon model of the domain structure of RXFP1. (b) H2 relaxin interacts and binds to the linker and LRR domain of RXFP1. (c) Binding of H2 relaxin stabilizes and extends a helix within the linker to orient and enable interactions of the LDLa module and residues within the linker to exoloop-2 of the TMD to facilitate receptor activation. The TMD (blue), LRR domain (grey), LRR-LDLa linker (magenta) and LDLa module (cyan) of RXFP1 are indicated. Additional loops are coloured red with exoloop-2 (EL2) of the TMD annotated. H2 relaxin is coloured green.