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. 2016 Apr 19;9:90. doi: 10.1186/s13068-016-0502-5

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© Fu et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The meso-2,3-BD biosynthetic pathway in B. subtilis. Enzymes overexpressed or introduced are underlined and depicted in green, and those interrupted are shown in red with a cross. Expanded names of enzymes and their coding genes: ALS acetolactate synthase, alsS; ALD acetolactate decarboxylase, alsD; ACK acetate kinase, ack; ALDH acetaldehyde dehydrogenase, adh; ADH alcohol dehydrogenase, ack; LDH lactate dehydrogenase, ldh; PDH pyruvate dehydrogenase, pdhABCD; PTA phosphotransacetylase, pta; PYC pyruvate carboxylase; E1, d-(−)-butanediol dehydrogenase (EC 1.1.1.4), bdhA; E2, L-(+)-butanediol dehydrogenase (EC 1.1.1.76), budC