Fig. 6.

The putative model of HMGA1-mediated activation of transcription. The putative mechanism of transcriptional regulation by HMGA1: HMGA1 promotes chromatin reorganization by exposing DNA sites for transcription initiation factors. A – HMGA1 competes with histone H1 by replacing it. B – chromatin decompactization using chromatin-remodeling complexes (CRCs). Binding of CRC to chromatin increases when it interacts with HMGA1. C – release of DNA for binding to transcription factors. D – initiation of transcription: HMGA1 can interact with transcription factors (TFs) by recruiting them to the promoter [62].