Table 1.

Antiviral activity of Hp-ACG and ACV in a Vero E6 cell culture [18, 19]

Compound	Characteristic	Virus
		HSV-1/L2	HSV-1/L2/R	Avd	Sha
Hp-ACG	ID50, μg/ml	15.6	31.25	31.25	31.25
	ID95, μg/ml	31.25	62.5	250	62.5
	SI	> 64	> 32	> 32	> 32
ACV	ID50, μg/ml	0.39	> 400	3.9	12.5
	ID50, μg/ml	1.56	> 400	31.25	50
	SI	> 1026	> 1	> 102	> 32

Note. HSV-1/L2 – reference virus strain; HSV-1/L2/R – laboratory virus strain highly resistant to ACV; Avd and Sha – ACV-resistant clinical isolates of HSV-1. Multiplicity of infection – 0.1 PFU/cell. Duration of incubation – 48 h. The results of two independent experiments are presented. CTD50 for ACV and Hp-ACG equal > 400 and > 1000 μg/ml, respectively. SI was calculated as the ratio of CTD50 to ID50.