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. 2016 Apr 20;36(16):4600–4613. doi: 10.1523/JNEUROSCI.4253-15.2016

Figure 3.

Figure 3.

Bdnf+/− mice are behaviorally insensitive to reinforcer devaluation. a, Bdnf+/− mice expressed approximately half as much BDNF in hippocampal lysates as wild-type littermates (n = 11–12 per group). b, Mice acquired the nose-poke response without differences between groups. c, Mice also consumed equivalent amounts of food under ad libitum conditions. d, After freely consuming reinforcer pellets, however, only wild-type mice significantly decreased response rates, whereas Bdnf+/− mice failed to significantly modify response patterns. e, Nonetheless, the same mice consumed equivalent amounts of a palatable sucrose solution (SUC; n = 16 wild-type, 12 Bdnf+/− littermates). Bars and symbols represent means ± SEMs per group, *p < 0.05; **p < 0.001. wt, Wild-type.