Signaling lipids involved in platelet function are increased in impaired healing. (A) Cyclooxygenase (COX)-mediated AA metabolite thromboxane A2, measured by thromboxane B2 (TXB2) levels, are significant increased during the first 3 days of healing suggesting enhanced platelet activity and increases in platelet aggregation. (B) 6kPGF1α is stable metabolite of prostaglandin I2 (PGI2), was significantly increased from day three to day 7 postwounding as a response to the enhanced platelet aggregation. n = 4. All data are Mean ± SD. *p<0.05, **p<0.01, ***p<0.001.