Figure 3.

Changes in ROS generation by ESR technology in guinea pigs. Animal grouping, noise exposure methods, and statistical treatment are consistent with Figure 1. Δ_ROS = Relative value of ROS, Δ_ROS = h/w (cm/g). Δ_ROS was statistically different by time after noise exposure compared to normal animals, and statistically different by drug administered group from the noise exposure group. The ROS level of the intravenous injected edaravone solution and intravenous injected edaravone SLNs groups remained elevated on the 1^st day, and the intratympanic injected edaravone solution and intravenous injected edaravone SLNs groups remained elevated on the 4^th day, while the edaravone SLNs groups showed some recovery on the 6^th day. */†P < 0.05, P < 0.01.