Table 1.

Drosophila Class III genes and human orthologs

Drosophila Gene	Human Ortholog	Full Gene Name (Human)	Function
Keap1	KEAP1	Kelch-like ECH-associated protein 1	Inhibitor of Nrf2
Gclc	GCLC	Glutamate-cysteine ligase, catalytic subunit	Oxidation/Reduction
Cyp6v1	TBXAS1	Thromboxane A synthase 1	Lipid metabolism Oxidation/Reduction
Cpr	POR	P450 oxidoreductase	Lipid metabolism Oxidation/Reduction
CG9436	AKR1D1	Aldo-keto reductase family 1, member D1	Lipid metabolism Oxidation/Reduction
CG31523	ELOVL1	ELOVL fatty acid elongase 1	Lipid metabolism
Sap-r	PSAP	Prosaposin	Lipid metabolism
Lpin	LPIN1	Lipin 1	Lipid metabolism Transcription/Nuclear receptor signaling
PCB	PC	Pyruvate carboxylase	Lipid metabolism Glycolysis/Gluconeogenesis
Aldh-III	ALDH3A1	Aldehyde dehydrogenase 3 family, member A1	Glycolysis/Gluconeogenesis
Rpn13	ADRM1	Adhesion regulating molecule 1	Proteasome-mediated processes
Pomp	POMP	Proteasome maturation protein	Proteasome-mediated processes
Prosalpha7	PSMA3	Proteasome subunit, alpha type, 3	Proteasome-mediated processes
Prosalpha3	PSMA4	Proteasome subunit, alpha type, 4	Proteasome-mediated processes
Rpn10	PSMD4	Proteasome 26S subunit, non- ATPase, 4	Proteasome-mediated processes
Rpn7	PSMD6	Proteasome26S subunit, non- ATPase, 6	Proteasome-mediated processes
Npl4	NPLOC4	Nuclear protein localization 4 homolog	Proteasome-mediated processes
TER94	VCP	Valosin containing protein	Proteasome-mediated processes Autophagy
Smr	NCOR2	Nuclear receptor corepressor 2	Transcription/Nuclear receptor signaling
Kr-h1	ZNF143	Zinc finger protein 143	Transcription
bru-2	CELF2	CUGBP, Elav-like family member 2	mRNA processing
CG10353	ANO4	Anoctamin 4	Ion transport
Rab8	RAB10	RAB10, member RAS oncogene family	Intracellular protein transport