Figure 3.

Lung and liver injuries in septic mice. After receiving miRZip-195 or miRZip000, mice were challenged with feces injected into the peritoneum or with saline in the presence of Pim-1 inhibitor II or vehicle. Six hours later, myeloperoxidase (MPO) activity was measured in lung tissues (A), and pulmonary microvascular albumin leak was determined (B). Alanine aminotransferase (ALT) activity (C) and aspartate aminotransferase (AST) activity (D) were measured in plasma. Data are mean ± SD (n = 6). *P < .05 vs sham or vehicle, ^†P < .05 vs miRZip000 + feces, and ^‡P < .05 vs miRZip-195 + feces.