Figure 2.

AT-1001 a partial agonist at the human α3β4 receptors. (A and B) (A) Typical currents evoked by a brief pulse (10 s) of acetylcholine (ACh), AT-1001, and ACh were recorded in cell at 5-min intervals, which is sufficient to allow full recovery of the response under control conditions. As seen from the trace, 100 μM AT-1001 evokes only a fraction of the ACh current and causes inhibition of the subsequent ACh response. (B) Histograms illustrating the response, normalized to unity versus the current evoked by ACh. Bars indicate the SEM obtained for eight cells.