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Nicotine flux versus product design and topography parameters for three hypothetical products. Nicotine flux is indicated by color. A hypothetical regulatory target range for product effectiveness is given as 25–45 μg/s. The areas enclosed by each product box represent the ranges of possible nicotine fluxes given the possible product characteristics (e.g., design, element, and liquid) and puff topography (e.g., puff duration and interpuff interval).
