Table 2.

Association Results of Top 20 Significant SNPs With AIWG in Discovery and Replication Cohorts

Chromosome	SNP	Position	Genes	Location	Allelea	NMISS	Discovery Cohort			Replication Cohort
							BETAb	STATc	P GWAS d	BETA	STAT	P Replication
9	rs10977144	8464233	PTPRD	intron	T/C	534	1.421	5.857	9.26E-09	0.392	2.868	4.30E-03
9	rs10977154	8473347	PTPRD	intron	T/C	534	0.9929	5.549	4.53E-08	0.3184	2.741	6.33E-03
5	rs12386481	179766091	GFPT2	5UTR	A/G	533	−0.8954	−5.306	1.98E-07	−0.4976	−2.677	7.65E-03
2	rs2046545	114417849	ACTR3	intron	G/A	534	−0.9236	−4.737	2.79E-06	−0.3423	−2.722	6.71E-03
6	rs1886243	35225377	TCP11	5UTR	G/T	534	−0.5323	−4.719	3.03E-06	−0.4961	−2.596	9.70E-03
9	rs10124277	8489295	PTPRD	intron	T/C	534	0.4381	4.711	3.15E-06	0.2754	2.831	4.81E-03
9	rs2296102	8479105	PTPRD	intron	T/G	534	0.9216	4.692	3.45E-06	0.4739	2.776	5.70E-03
5	rs3853114	13534754	LOC391738 e	3UTR	C/T	534	−0.4231	−4.644	4.32E-06	−0.1973	−2.125	0.03401
1	rs4649328	231737008	KCNK1	5UTR	T/C	534	0.4078	4.434	1.13E-05	0.3708	2.287	0.0226
10	rs7906629	90048617	RNLS f	intron	A/C	534	−0.4843	−4.301	2.02E-05	−0.4075	−2.666	7.90E-03
10	rs1426621	90085709	RNLS	intron	T/G	534	−0.432	−4.287	2.15E-05	−0.2575	−2.645	8.40E-03
5	rs6449807	65635596	FLJ46010	intron	T/C	534	0.4527	4.286	2.17E-05	0.1686	1.693	0.091
4	rs4861124	41337646	LIMCH1	intron	G/A	534	−0.4329	−4.237	2.68E-05	0.1376	0.8643	0.3878
3	rs7611808	132828435	CPNE4	intron	G/A	534	−1.363	−4.199	3.15E-05	−0.5232	−3.026	2.59E-03
9	rs13286274	8466459	PTPRD	intron	T/C	534	1.213	4.187	3.31E-05	0.1529	1.172	0.2418
8	rs2929104	40030807	INDOL1	3UTR	T/G	534	1.388	4.18	3.41E-05	0.2708	2.098	0.03636
6	rs6915627	35236308	TCP11	5UTR	A/G	534	−0.3937	−4.163	3.66E-05	−0.1294	−1.163	0.2452
6	rs2195729	123631825	TRDN	intron	C/T	534	−0.3874	−4.152	3.83E-05	0.2817	2.201	0.02818
9	rs882895	129854187	C9orf90	3UTR	A/G	532	−0.3952	−4.115	4.49E-05	−0.2115	−2.287	0.02256
3	rs13076635	31825509	OSBPL10	intron	A/G	533	0.564	4.115	4.49E-05	0.2754	2.831	4.81E-03

^aMinor/major alleles.

^bBETA means the regression coefficient of the log-linear analysis.

^cSTAT refers to the coefficient t-statistic of log-linear analysis.

^d P _GWAS are P values corrected by using log-linear association at GWAS level, with age and gender as covariates.

^eLOC391738 is also known as RPL29P13.

^fRNLS is also known as C10orf59.