Table 3.

Hazard Ratios for Macrovascular, Microvascular Complications, and Mortality of Schizophrenia by Antipsychotic Use

	All Complications	Macrovascular Complications	Microvascular Complications	All-Cause Mortality
	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
Antipsychotic use vs no use
Irregular use	0.90 (0.78–1.03)	0.83 (0.70–0.98)*	0.99 (0.81–1.22)	0.79 (0.69–0.90)*
Regular use, overall	0.81 (0.69–0.95)*	0.80 (0.66–0.97)*	0.83 (0.62–1.11)	0.73 (0.62–0.85)*
Low metabolic risk	0.85 (0.70–1.02)	0.84 (0.67–1.06)	0.83 (0.62–1.11)	0.66 (0.54–0.81)*
Intermediate metabolic risk	0.82 (0.68–0.99)*	0.81 (0.64–1.02)	0.83 (0.62–1.10)	0.78 (0.65–0.94)*
High metabolic risk	0.69 (0.53–0.91)*	0.74 (0.53–1.02)	0.61 (0.40–0.93)*	0.62 (0.47–0.82)*
Combination use	0.84 (0.66–1.08)	0.75 (0.55–1.04)	1.03 (0.72–1.46)	0.82 (0.65–1.05)
Benzodiazepine use vs no use
Irregular use	0.99 (0.87–1.14)	1.11 (0.95–1.31)	0.82 (0.67–1.00)	1.11 (0.98–1.27)
Regular use	0.96 (0.82–1.12)	0.97 (0.80–1.17)	0.86 (0.68–1.08)	1.25 (1.07–1.47)

Note: HR, hazard ratio.

*P value < .05.