Fig. 6.

Deletion of HIF1-α and HIF2-α within vascular endothelium is protective against the development of pulmonary hypertension and cardiac remodeling in a model of chronic hypoxia. A: RVSP increased to a greater degree with hypoxia exposure in littermate controls compared with endothelial HIF1/2 KO mice. B: right-ventricular remodeling was more prominent with hypoxia exposure in littermate controls compared with endothelial HIF1/2 KO mice, which had an index similar to baseline values. C: consistent with this finding, small pulmonary vessels displayed increased evidence of complete muscularization in control animals exposed to hypoxia, vs. HIF1/2 KO mice. n = 18 per group, *P < 0.05.