Table I.
Enriched GO biological processes of the DEGs in the protein-protein interaction networks.
| Term and function | Count | Genes | P-value | FDR |
|---|---|---|---|---|
| Upregulated DEGs | ||||
| GO:0046822 - Regulation of nucleocytoplasmic transport | 7 | CDKN2A, TGFBR1, SMAD3, CDH1, TACC3, FLNA, TGFB1 | 1.72×10−6 | 0.002848 |
| GO:0032880 - Regulation of protein localization | 9 | TGFBR1, SMAD3, CDH1, CDH2, CASP1, TACC3, FLNA, TGFB1, IL1A | 2.60×10−6 | 0.004308 |
| GO:0051222 - Positive regulation of protein transport | 7 | TGFBR1, SMAD3, CDH1, CASP1, FLNA, TGFB1, IL1A | 4.05×10−6 | 0.006710 |
| GO:0032386 - Regulation of intracellular transport | 7 | CDKN2A, TGFBR1, SMAD3, CDH1, TACC3, FLNA, TGFB1 | 5.69×10−6 | 0.009436 |
| Downregulated DEGs | ||||
| GO:0043085 - Positive regulation of catalytic activity | 13 | ADCY1, PTGER3, CCKBR, C6, C5, LPAR3, EDNRB, PRKAR2B, PLCE1, CLPS, GNAS, EGF, PSMD6 | 1.72×10−5 | 0.027131 |
| GO:0010033 - Response to organic substances | 15 | TF, ADCY1, PNLIPRP1, GATM, PDE3B, EPHX1, CFTR, PDE3A, NPY1R, PRKAR2B, ABAT, ANGPT1, GNAS, SST, GNG7 | 2.20×10−5 | 0.034801 |
| GO:0009725 - Response to hormone stimuli | 11 | PRKAR2B, PNLIPRP1, ADCY1, GATM, PDE3B, GNAS, ANGPT1, CFTR, NPY1R, SST, GNG7 | 2.29×10−5 | 0.036206 |
| GO:0006575 - Cellular amino acid derivative metabolic processes | 8 | GSTA1, P4HB, CTH, GATM, GPX3, ABAT, GAMT, GNMT | 2.78×10−5 | 0.043955 |
FDR, false discovery rate; DEG, differentially-expressed genes; GO, gene ontology.