Table 1. Risk factors associated with paradoxical reactions.
| Risk factor | PR | No PR | OR (95%CI) | p-value | |
|---|---|---|---|---|---|
| Age mean (SD) | 15.2 (12.5) | 16.5 (13.4) | N/A | 0.529* | |
| Gender n (%) | Female | 36 (24%) | 117 (76%) | 1 | |
| Male | 16 (18%) | 72 (88%) | 0.72 (0.37–1.40) | 0.416ǂ | |
| WHO categoryn (%) | CAT 1 | 7 (10%) | 62 (90%) | 1 | |
| CAT 2 | 36 (27%) | 97 (73%) | 3.29 (1.38–7.87) | 0.007ǂ | |
| CAT 3 | 9 (23%) | 30 (77%) | 2.66 (0.90–7.81) | 0.076ǂ | |
| site of lesion n (%) | Lower limb | 20 (17%) | 97 (83%) | 1 | |
| Upper limb | 24 (24%) | 76 (76%) | 1.54 (0.79–2.94) | 0.209ǂ | |
| Trunk | 8 (44%) | 10 (56%) | 3.88 (1.36–11.1) | 0.011ǂ | |
| Type of lesion n (%) | Ulcerative | 29 (20%) | 113 (80%) | 1 | |
| Non-ulcerative | 23 (23%) | 76 (76%) | 1.18 (.64–2.19) | 0.602ǂ | |
| Vitamin D nmol/Lmean (SD) | 66.5 (19.1) | 68.3 (17.1) | N/A | 0.631* | |
| 3’UTR TGTG n (%) | ins/ins | 22 (31%) | 48 (69%) | 1 | |
| ins/del | 4 (6%) | 63 (94%) | 0.14 (0.05–0.44) | 0.001ǂ | |
| del/del | 1 (13%) | 7 (87%) | 0.44 (0.04–4.55) | 0.494ǂ | |
| D543N n (%) | G/G | 25 (21%) | 96 (79%) | 1 | |
| G/A | 2 (8%) | 23 (92%) | 3.00 (0.66–13.51) | 0.155ǂ | |
| A/A | 0 (0%) | 0 (0%) | N/A | ||
| INT4 n (%) | G/G | 21 (17%) | 105 (83%) | 1 | |
| G/C | 5 (28%) | 13 (72%) | 1.56 (.55–4.43) | 0.405ǂ | |
| C/C | 1 (100%) | 0 (0%) | N/A | ||
| 5’(CA)n n (%) | 200/200 | 9 (14%) | 60 (86%) | 1 | |
| 200/other | 17 (25%) | 52 (75%) | 2.18 (.90–5.30) | 0.086ǂ | |
| other/other | 1 (13%) | 7 (87%) | 0.98 (.32–2.95) | 0.975ǂ |
* = t-test
ǂ = Binary logistic regression, PR = paradoxical reaction, OR = Odds ratio, CI = confidence interval.