Table 1. Percentages (%) of mouse embryos developing into different pre-implantation stages after microinjection of LIF-siRNA or scrambled-siRNA at the two-pronuclear stage.
Untreated (n = 51) | Solution (n = 30) | scramble (n = 87) | LIF-siRNA (n = 24) | ||
---|---|---|---|---|---|
Two-cell | 90.2 | 93.3 | 93.1 | 91.7 | |
Four-cell | 85.7 | 86.7 | 92.0 | 75.0 | |
Morula | 83.4 | 83.3 | 89.7 | 58.3a | |
Blastocyst | 83.4 | 80.0 | 86.2 | 41.7a |
aP<0.05 compared with the untreated group.