Fig 1. Summary of features differentiating Omics Integrator from existing tools and which features are available when Garnet and Forest are used individually.

¹ Some network algorithms model TFs by including protein-DNA interactions in the network or generating TF scores for the protein nodes. ² Some network algorithms optimize the transmission of information from source nodes to target nodes and require the sources to be identified in advance. ³ Time series analysis algorithms require omic data from three or more time points. ⁴ Intermediate proteins, like the Steiner nodes predicted by Forest, are not assigned condition-specific scores but are important for connecting other scored nodes in the subnetwork. ⁵ Negative evidence discourages network algorithms from selecting particular nodes due to prior knowledge or a bias, such as node degree.