Table 3. Comparison of virus and disease severity of the main cohort considering the virus as single pathogen or as co-infection in the sample.
Different statistical models were considered to study the bivariate association between the variables depending on the dependent variable. A binary logistic model was used for the binary variables oxygen needed and respiratory support needed, and a negative binomial regression model for counted data (hospital stay length). Data are presented as OR (confidence interval 95%) and the level of statistical significance was set at 0.05.
| Risk Factor | Hospital stay length | Oxygen needed | Respiratory support | Wood Downes score | GENVIP score | PICU admission | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (n = 163) | (n = 186) | (n = 186) | (n = 177) | (n = 125) | (n = 119) | |||||||
| OR (95% CI) | P -value | OR (95% CI) | P -value | OR (95% CI) | P–value | Coefficient (95% CI) | P -value | Coefficient (95% CI) | P -value | OR (95% CI) | P -value | |
| Mono-infected | ||||||||||||
| RSV | 1.092 | 0.450 | 3.154 | 0.012 | 3.556 | 0.122 | 0.571 | 0.188 | 1.384 | 0.107 | 1.121 | 0.846 |
| (0.868, 1.374) | (1.302, 7.966) | (0.832, 24.487) | (-0.284,1.425) | (-0.307, 3.075) | (0.362, 3.728) | |||||||
| Rhinovirus | 0.785 | 0.154 | 0.327 | 0.042 | 1.167 | 0.854 | -0.823 | 0.144 | -1.134 | 0.447 | 1.410 | 0.623 |
| (0.562, 1.094) | (0.109, 0.962) | (0.165, 5.257) | (-1.932, 0.285) | (-4.095, 1.826) | (0.330, 5.410) | |||||||
| Bocavirus | 0.999 | 0.997 | 0.435 | 0.327 | -0.187 | 0.859 | -2.610 | 0.111 | ||||
| (0.646, 1.548) | (0.076, 2.482) | (-2.270, 1.897) | (-5.840, 0.619) | |||||||||
| Adenovirus | 1.211 | 0.456 | 0.859 | 0.413 | 1.581 | 0.624 | ||||||
| (0.733, 2.019) | (-1.217, 2.935) | (-4.841, 8.002) | ||||||||||
| Co-infected | ||||||||||||
| RSV | 1.150 | 0.281 | 0.938 | 0.892 | 1.550 | 0.456 | -0.222 | 0.646 | 0.243 | 0.815 | 1.426 | 0.597 |
| (0.892, 1.481) | (0.361, 2.364) | (0.509, 5.328) | (-1.217, 2.935) | (-1.829, 2.316) | (0.402, 5.887) | |||||||
| Rhinovirus | 1.443 | 0.003 | 1.642 | 0.288 | 2.921 | 0.085 | 1.289 | 0.006 | 0.920 | 0.379 | 2.169 | 0.146 |
| (1.135, 1.836) | (0.658, 4.158) | (0.923, 11.199) | (0.387, 2.192) | (-1.157, 2.997) | (0.104, 1.398) | |||||||
| Bocavirus | 0.697 | 0.003 | 1.243 | 0.642 | 0.889 | 0.832 | -0.654 | 0.168 | -0.551 | 0.589 | 1.174 | 0.794 |
| (0.551, 0.883) | (0.499, 3.168) | (0.290, 2.632) | (-1.590, 0.282) | (-2.583, 1.481) | (0.352, 3.910) | |||||||
| Adenovirus | 0.938 | 0.613 | 1.000 | 1.000 | 0.682 | 0.515 | 0.290 | 0.553 | -0.848 | 0.422 | 1.426 | 0.597 |
| (0.730, 1.204) | (0.396, 2.604) | (0.198, 22.080) | (-0.677, 1.257) | (-2.947, 1.252) | (0.383, 5.305) | |||||||