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. 2016 Mar 3;4(1):e1156287. doi: 10.1080/21675511.2016.1156287

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — Description of the pigmentation-based forward genetic screen in albino mice. Albino mice are unpigmented due to a G to C nucleotide change at position 308 of the Tyr gene, causing a cysteine to serine mutation at amino acid 103 of the Tyrosinase protein. Reintroduction of a functional Tyr gene via transgenesis can rescue the albino phenotype. Tyr transgene-induced pigmentation is uniform if inserted in a locus not important for NCC and not uniform if inserted in a locus important for NCC.