Table 2. mRNA expression changes for selected genes.
| Entrezid | P-value | FLT/AEM (log2) | |
|---|---|---|---|
| Lipid Droplets | |||
| Cidec | 14311 | 3.82E-06 | 2.501 |
| Pnpla2 | 66853 | 9.19E-06 | 1.436 |
| Plin5 | 66968 | 1.13E-05 | 1.022 |
| Plin4 | 57435 | 2.30E-03 | 0.932 |
| Plin2 | 11520 | 8.61E-05 | 0.782 |
| Plin3 | 66905 | 6.47E-04 | 0.444 |
| Stellate Cell Activation | |||
| Lamb3 | 16780 | 1.17E-04 | 0.972 |
| Lepr | 16847 | 1.58E-02 | 0.787 |
| Serpine1 | 18787 | 3.58E-03 | 0.442 |
| Tgfbr3 | 21814 | 7.69E-04 | 0.423 |
| Tgfbr2 | 21813 | 3.54E-03 | 0.39 |
| Tgfbr1 | 21812 | 8.26E-03 | 0.362 |
| Col3a1 | 12825 | 2.94E-02 | -0.179 |
| Lama4 | 16775 | 2.95E-02 | -0.193 |
| Mmp2 | 17390 | 3.46E-04 | -0.21 |
| Col1a1 | 12842 | 1.52E-02 | -0.221 |
| Mmp19 | 58223 | 3.07E-04 | -0.383 |
| Vim | 22352 | 3.65E-01 | -0.126 |
| Des | 13346 | 3.82E-01 | -0.122 |
| Acta2 | 11475 | 2.24E-01 | -0.238 |
| Thioesterases | |||
| Acot2 | 171210 | 1.15E-05 | 2.055 |
| Acot1 | 26897 | 5.06E-06 | 1.357 |
| Acot5 | 217698 | 1.30E-04 | 1.189 |
| Acot8 | 170789 | 1.24E-06 | 0.856 |
| Ketogenesis | |||
| Bdh1 | 71911 | 5.95E-04 | 1.008 |
| Acat1 | 110446 | 7.53E-05 | 0.474 |
| Hmgcl | 15356 | 8.32E-05 | 0.466 |
| Hadha | 97212 | 6.43E-05 | 0.314 |
| Triglyceride Biosynthesis | |||
| Agpat9 | 231510 | 3.20E-06 | 1.992 |
| Elovl3 | 12686 | 4.11E-05 | 1.865 |
| Lclat1 | 225010 | 8.00E-04 | 0.911 |
| Ppp2r2d | 52432 | 3.49E-05 | 0.814 |
| Agpat6 | 102247 | 7.65E-04 | 0.508 |
| Elovl1 | 54325 | 1.10E-03 | -0.473 |
| Elovl6 | 170439 | 3.09E-05 | -1.308 |
| Retinol Metabolism | |||
| Cyp4a31 | 666168 | 7.03E-05 | 1.427 |
| Retsat | 67442 | 7.85E-06 | 1.049 |
| Hsd17b6 | 27400 | 2.47E-02 | 0.702 |
| Bcmo1 | 63857 | 9.18E-03 | 0.565 |
| Cyp4a32 | 100040843 | 2.47E-02 | 0.514 |
| Lrat | 79235 | 4.68E-03 | -0.383 |
| Cyp2c68 | 433247 | 4.47E-03 | -0.513 |
| Dhrs3 | 20148 | 2.18E-03 | -0.521 |
| Cyp2c38 | 13097 | 1.97E-02 | -0.551 |
| Cyp2c70 | 226105 | 6.68E-04 | -0.568 |
| Cyp26a1 | 13082 | 3.06E-03 | -1.114 |
| PPARα targets | |||
| Gpd2 | 14571 | 6.20E-07 | 1.476 |
| Fgf21 | 56636 | 1.84E-05 | 1.018 |
| Cd36 | 12491 | 1.82E-03 | 0.868 |
| Slc27A1 | 26457 | 2.41E-04 | 0.673 |
| Ppargc1a | 19017 | 5.69E-02 | 0.467 |
| Gyk | 14933 | 9.29E-06 | 0.512 |
| FXR targets and bile acid metabolism | |||
| Fgf21 | 56636 | 1.84E-05 | 1.018 |
| Slc22a7 | 108114 | 9.75E-03 | 0.735 |
| Abcg5 | 27409 | 2.89E-03 | 0.614 |
| Baat | 12012 | 8.11E-04 | -0.284 |
| Hmgcr | 15357 | 2.62E-02 | -0.525 |
| Miscellaneous | |||
| Pparg | 19016 | 4.05E-03 | 0.965 |
| Cpt1a | 12894 | 8.26E-06 | 0.8 |
| Ucp2 | 22228 | 4.53E-02 | 0.471 |
Fold changes, P values are calculated using CARMAWeb. P < 0.05 is considered significant. The Entrez accession number is given by Entrezid.