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. 2015 Dec 9;44(7):3059–3069. doi: 10.1093/nar/gkv1353

Figure 6.

Figure 6.

Linc-RoR specifically regulates c-Myc by facilitating interaction of hnRNP I with c-Myc mRNA while inhibiting interaction of AUF1 with c-Myc mRNA. (A) Both AUF1 and hnRNP I interacts with c-Myc mRNA, as detected by RNA precipitation using c-Myc 3′-UTR as a probe, followed by western blot. (B) Linc-RoR KO enhances interaction of c-Myc mRNA with AUF1, as detected by RIP assay using AUF1 antibody. (C) Linc-RoR is required for interaction of hnRNP I with c-Myc mRNA, as detected by RIP assay using hnRNP antibody. (D) Linc-RoR KO enhances interaction of c-Myc mRNA with AUF1, but suppresses interaction of c-Myc mRNA with hnRNP I, as detected by RNA precipitation using c-Myc 3′-UTR probe. Error bars represent S.E.M., n = 3. **P < 0.01.